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KMID : 0525720110160010023
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Journal of Chitin and Chitosan
2011 Volume.16 No. 1 p.23 ~ p.26
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Inhibitory Effects of Low Molecular Weight Chitosan Oligosaccharide on Breast Cancer Development
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Lee Mi-Hyun
Jeong Sang-Bin
Shin Jin-Sun
Lee Kyu-Shik
Nam Kyung-Soo
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Abstract
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We investigated the effect of low molecular weight chitosan oligosaccharide (COS-L, Mw < 1,000) on breast cancer development and progression through the measurement of quinone reductase (QR) activity and glutathione (GSH) content and the determination of ornithine decarboxylase activity (ODC) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). In a concentration range of 0.1 to 5 mg/mL, QR activity and GSH content in MCF-7 breast cancer cells were significantly increased maximal 76.5% and 56.3% by COS-L in a dose-dependent manner, respectively. Low molecular weight chitosan oligosaccharide effectively inhibited the activity of ODC, a key enzyme in cancer promotion. These results demonstrate that COS-L may prevent the development and promotion of breast cancer through the induction of QR activity, the increase of GSH content and the inhibition of ODC activity.
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KEYWORD
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chitosan oligosaccharide, breast cancer, quinone reductase, glutathione, ornithine decarboxylase
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